ALTHEA Mab Discovery Platform

What are the ALTHEA Gold Libraries™?

The ALTHEA Gold Libraries™ are advanced semi-synthetic human antibody libraries for therapeutic applications. The libraries were designed for optimal functionality and developability.

  • Unique platform for antibody discovery.

  • One VH scaffold and two VL scaffolds provide different paratope configurations

  • Choice of vector, tags, and helper phage (M13KO7, CM13, CM13d3).

  • All CDR-H3 are of human origin.

  • High diversity with >20 billion clones in scFv format.

  • Proven record of antibody discovery & publications in peer reviewed journals.

  • Simple and affordable commercialization strategy including direct access to libraries.

The ALTHEA Gold Libraries™ were developed by Antibody Design Labs in the US in 2018.

A Unique Construction Process

An innovative 3-step thermo-filtration strategy eliminates unfit clones and selects for thermostable, developable antibodies.

A Carefully Designed Diversity

Sequence diversity is concentrated specifically in the CDRs, at key antibody-antigen interaction sites that were identified through comprehensive analysis of known antibody-antigen structures. A subsequent shuffling using H3J fragments derived from human donors resulted in a 100-fold increase in diversity and a 50% increase in thermostability.

A Dual Frameworks For Antigen Recognition

The antibody’s ability to recognize antigens relies on its binding site, called the paratope. The ALTHEA Gold libraries™ utilize two different framework combinations, VH3-23/VL3-20 and VH3-23/VL34-01, to modulate the shape of the paratope and enable the recognition of a wide range of potential protein & peptide targets.

Antibodies to Any Targets!

A typical screening of the ALTHEA Gold libraries™ leads to multiple binders in only 3 rounds of panning. Additiontal rounds of solution capture identifies the best binders. Cross-selection identify reactive clones to the cynomolgus and murine homologs.

A Proven Record of Publications

Original Publication

1. Valadon P. & al. (2019). MAbs. 2019; 11(3):516-531.

Citations

2. Vidal-Calvo EE et al. (2024). Nat Commun. 2024;15(1):7553.
3. Guzmán-Bringas OU et al. (2023). Int J Mol Sci. 2023.
4. Mendoza-Salazar I et al. (2022). 2022;11(1):13.
5. Dao T et al. (2022). PLoS One. 2022;17(3):e0265534.
6. Dao T et al. (2022). JCI Insight. 2022;7(5):e151624.
7. Pedraza-Escalona M et al. (2021). BMC Infect Dis. 2021 Oct 30;21(1):1121.

Reviews

8. Zhang Y. (2023). MAbs. 2023;15(1):2213793.
9. Almagro JC et al. (2019)Antibodies (Basel). 2019 Aug 23;8(3):44.

Work with Us

Discovery Process

We offer access to the ALTHEA Gold Libraires™ through customized discovery campaign as a service or directly in your own platform through a simple and affordable commercialization strategy with full access to the libraries.

  • Sample kits for single targets for your in-house platform

  • Library acquisition

  • Customized Discovery Campaigns

    • Varied selection strategies

    • Counter selection, competitive selection, cross-species selection

    • Off-rate selection

    • Sandwich pair selection

    • Anti-idiotype antibodies

    • Common epitope identification

    • Cell surface selections

    • NGS-guided selection

  • Affinity maturation in Fab format

  • Developability analysis

  • Reformatting & Expression

Request a Quote

Contact Us

Please, request a quote by completing the online quotation form accessible by pressing this button; you will be contacted back by the next business day. All our work is performed by highly experienced staff at our San Diego facility in California. All products and services are for research use only and not intended for use in humans. For all other inquiries, contact us by email at info@abdesignlabs.com or by phone at 1-877-223-3104 (PST).

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