In a ground breaking work, Skora et al. just published in the Proceeding of the National Academy of Sciences the isolation of “manabodies” or antibodies that binds mutation-associated neo-antigens (Proc Natl Acad Sci U S A. 2015; 112(32):9967-72). Antibodies associated to cancer related mutated peptides presented by MHC molecules are notoriously difficult to isolate. This achievement was made through the use of the pADL-10b phagemid vector.